Influenza has affected humans for over 6,000 years, causing pandemics at regular intervals. During the 1918 Spanish flu, it was thought to be a bacteria, until an American physician Richard Shope identified the virus in 1931. The Conversation So how is it this pathogen has managed to stay around for so long, and why haven’t we beaten it yet? The answer is that influenza is a virus that changes rapidly and regularly. New flu vaccines are required every year due to these changes and mutations of the virus. While all flu viruses which infect humans are similar, a pandemic virus (which is easily transmitted between humans) is significant because humans have no immunity to it, and so are vulnerable to severe infection and death. Seasonal viruses which we see year after year were once pandemic strains, but humans have now been exposed to these viruses and have some background immunity to them. We have found that the last decade has seen an acceleration in the number of flu strains inf