Skip to main content

Liver fibrosis can be detected through blood test: new study (downtoearth)

Doctors have long been using biopsy to diagnose liver fibrosis. A new study says it may be possible to diagnose the liver disease with a blood test in future.

Researchers at the All India Institute of Medical Science (AIIMS), New Delhi, working in collaboration with Justus Liebig University in Germany, have identified diagnostic markers for liver fibrosis. With these markers, it will be possible to diagnose liver fibrosis from blood samples. It will make diagnosis easier to perform, non-invasive, and less prone to sampling errors, researchers say in their study published in journal Clinical and Translational Gastroenterology.

The new study has reported that patients of liver fibrosis have elevated levels of two proteins—Cathepsin L and Cathepsin B—in liver tissues as well as blood plasma, compared to healthy people. The increased levels of these two proteins open the possibility of designing a new and better diagnosis for liver disease. There is progressive increase in concentrations of the two proteins with advancement in the stages of liver cirrhosis, making them potential diagnostic tools.

The observation was first made in animals and then humans. It was seen that the two proteins are elevated in kidney, heart, and lung fibrosis, which led to the idea of testing their diagnostic relevance in liver disorder. Since the findings are based on blood samples from 51 patients, researchers have recommended studies involving larger group of patients to further validate their work.

However, an expert working in the same field pointed out that “previous studies have also reported biomarkers for liver fibrosis. The challenge is to find a marker that can differentiate between mild and severe stages of the disease in addition to distinguishing between healthy and severely ill conditions.”

Liver fibrosis is caused by several factors including alcohol consumption, viral infection, and metabolic disorders. It is also congenital in some cases. It is marked by the formation of scars and nodules in the liver, which is due to accumulation of specific proteins.

The study team included Mansi Manchanda, Prasenjit Das, Gaurav Gahlot, Ratnakar Singh, Elke Roeb, Martin Roderfeld, Siddhartha Datta Gupta, Anoop Saraya, R M Pandey and Shyam S Chauhan.(India Science Wire)


Popular posts from this blog

SC asks Centre to strike a balance on Rohingya issue (.hindu)

Supreme Court orally indicates that the government should not deport Rohingya “now” as the Centre prevails over it to not record any such views in its formal order, citing “international ramifications”.

The Supreme Court on Friday came close to ordering the government not to deport the Rohingya.

It finally settled on merely observing that a balance should be struck between humanitarian concern for the community and the country's national security and economic interests.

The court was hearing a bunch of petitions, one filed by persons within the Rohingya community, against a proposed move to deport over 40,000 Rohingya refugees. A three-judge Bench, led by Chief Justice of India Dipak Misra, began by orally indicating that the government should not deport Rohingya “now”, but the government prevailed on the court to not pass any formal order, citing “international ramifications”. With this, the status quo continues even though the court gave the community liberty to approach it in …

Cloud seeding

Demonstrating the function of the flare rack that carries silver iodide for cloud-seeding through an aircraft. 
Water is essential for life on the earth. Precipitation from the skies is the only source for it. India and the rest of Asia are dependent on the monsoons for rains. While the South West Monsoon is the main source for India as a whole, Tamil Nadu and coastal areas of South Andhra Pradesh get the benefit of the North East Monsoon, which is just a less dependable beat on the reversal of the South West Monsoon winds.

India’s criminal wastage: over 10 million works under MGNREGA incomplete or abandoned (hindu)

In the last three and half years, the rate of work completion under the Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA) has drastically declined, leading to wastage of public money and leaving villages more prone to drought. This could also be a reason for people moving out of the programme.

At a time when more than one-third of India’s districts are reeling under a drought-like situation due to deficit rainfall, here comes another bad news. The works started under the MGNREGA—close to 80 per cent related to water conservation, irrigation and land development—are increasingly not being completed or in practice, abandoned.

Going by the data (as on October 12) in the Ministry of Rural Development’s website, which tracks progress of MGNREGA through a comprehensive MIS, 10.4 million works have not been completed since April 2014. In the last three and half years, 39.7 million works were started under the programme. Going by the stipulation under the programme, close to 7…